The quantification of angiogenesis in relation to metastasis in oral cancer: a review

The quantification of angiogenesis in relation to metastasis in oral cancer: a review
Accepted 16 April 2003
E.J.M. Hannenaf1, D. Riedigerb
International Journal of Oral & Maxillofacial Surgery

Abstract
Tumours need vessels to grow into clinically significant dimensions, and to metastasize. Varying results have been reported for the relation between angiogenic activity in oral carcinomas, and the occurrence of metastasis. Quantification of microvessels in tissue sections is mostly used to assess angiogenesis, but appears subject to biases as reflected in contradicting reports. Especially the choice of immunohistochemical staining technique appears pivotal. Although microvessel density measurements (MVD) appear promising for other tumour types, in oral carcinomas no unambiguous relation could be established. Furthermore, MVD assessment appears more elaborate than expected. New, more time efficient techniques may replace MVD as we know it.

Keywords: neoplasm blood supply, neovascularization, head and neck neoplasms, squamous cell carcinoma, oral carcinoma, review literature, diagnostic techniques and procedures, patient care planning.
No full text is available.To read the body of this article, please view the PDF online.

a Department of Oral and Maxillofacial Surgery, Catharina-Hospital Eindhoven, The Netherlands

b Department of Cranio Maxillofacial Surgery, Head and Neck Surgery, University Hospital Maastricht, The Netherlands

f1 Address: Egied J. M. Hannen, D.M.D., M.D., Ph.D., Dept of Oral and Maxillofacial Surgery, Catharina-Hospital Eindhoven, The Netherlands, PO Box 1350, 5602 ZA Eindhoven, The Netherlands, Tel: +31 40 2397030; Fax: +31 40 2397032; E-mail: e.j.m.hannen@hccnet.nl

PII: S0901-5027(03)90433-4

doi:10.1054/ijom.2003.0433

© 2004 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

Copyright © 2007 Elsevier, Inc. All rights reserved

You can view the abstract online. A subscription is required to view the full text PDF or it can be purchased online.