The Role of Tumor Necrosis Factor Receptor Type 1 in Orthodontic Tooth Movement - Corrective Dentistry (Orthodontics) Articles

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http://jdr.iadrjournals.org/cgi/content/abstract/86/11/1089?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=orthodontics&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT

The Role of Tumor Necrosis Factor Receptor Type 1 in Orthodontic Tooth Movement
Journal of Dental Research 86(11):1089-1094, 2007

I. Andrade, Jr.1, T.A. Silva2,*, G.A.B. Silva3, A.L. Teixeira4, and M.M. Teixeira5
1 Department of Orthodontics, PontifÃcia Universidade Cat€lica de Minas Gerais (PUC-Minas), Faculty of Dentistry, Belo Horizonte/MG, Brazil;
2 Department of Oral Pathology, Universidade Federal de Minas Gerais, Faculty of Dentistry, Av. AntŸnio Carlos 6627, CEP 31.270-901, Belo Horizonte/MG, Brazil;
3 Department of Morphology, Universidade Federal de Minas Gerais, Instituto de CiÕncias Biol€gicas, Belo Horizonte/MG, Brazil;
4 Department of Clinical Medicine, Universidade Federal de Minas Gerais, Faculty of Medicine, Belo Horizonte/MG, Brazil; and
5 Department of Biochemistry and Immunology, Instituto de CiÕncias Biol€gicas, Universidade Federal de Minas Gerais, Belo Horizonte/MG, Brazil

* corresponding author, tarcilia@odonto.ufmg.br

Orthodontic tooth movement is dependent on osteoclast activity. Tumor necrosis factor (TNF)- plays an important role, directly or via chemokine release, in osteoclast recruitment and activation. This study aimed to investigate whether the TNF receptor type 1 (p55) influences these events and, consequently, orthodontic tooth movement. An orthodontic appliance was placed in wild-type mice (WT) and p55-deficient mice (p55Ò/Ò). Levels of TNF- and 2 chemokines (MCP-1/CCL2, RANTES/CCL5) were evaluated in periodontal tissues. A significant increase in CCL2 and TNF- was observed in both groups after 12 hrs of mechanical loading. However, CCL5 levels remained unchanged in p55Ò/Ò mice at this time-point. The number of TRAP-positive osteoclasts in p55Ò/Ò mice was significantly lower than that in WT mice. Also, there was a significantly smaller rate of tooth movement in p55Ò/Ò mice. Analysis of our data suggests that the TNFR-1 plays a significant role in orthodontic tooth movement that might be associated with changes in CCL5 levels.

KEY WORDS: orthodontic tooth movement Ô mechanical loading Ô bone remodeling Ô TNF- Ô chemokines

© 2007 International and American Associations for Dental Research