Streptococcus anginosus infection in oral cancer and its infection route

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Streptococcus anginosus infection in oral cancer and its infection route
Issue online:
11 May 2005
Received 30 March 2004; revised 17 June 2004; accepted 29 June 2004
To cite this article: M Sasaki, C Yamaura, Y Ohara-Nemoto, S Tajika, Y Kodama, T Ohya, R Harada, S Kimura (2005)
Streptococcus anginosus infection in oral cancer and its infection route
Oral Diseases 11 (3), 151Ò156.
doi:10.1111/j.1601-0825.2005.01051.x
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M Sasaki11Department of Oral Microbiology, C Yamaura11Department of Oral Microbiology, Y Ohara-Nemoto11Department of Oral Microbiology, S Tajika11Department of Oral Microbiology, Y Kodama11Department of Oral Microbiology, T Ohya22First Department of Oral and Maxillofacial Surgery, R Harada33Department of Pedodontics, Iwate Medical University School of Dentistry, Morioka, Iwate, Japan, S Kimura11Department of Oral Microbiology

Shigenobu Kimura, Department of Oral Microbiology, Iwate Medical University School of Dentistry, 1-3-27 Chuodori, Morioka, Iwate 020-8505, Japan. Tel: +81-19-622-1251, Fax: +81-19-622-1251, E-mail: kimuras@iwate-med.ac.jp

Abstract
Objective: To elucidate a possible involvement of Streptococcus anginosus in oral cancer, we assessed the frequency of S. anginosus infection in oral cancer tissues, and investigated its infection route.

Materials and method: The tissue specimens were obtained from 46 oral cancer and three precancerous leukoplakia subjects. Frequency of S. anginosus infection was assessed by a species-specific polymerase chain reaction (PCR) assay. The genotype of the clinical isolates taken from cancer tissue and dental plaque samples was analyzed using pulsed-field gel electrophoresis (PFGE).

Results: S. anginosus DNA was frequently detected in squamous cell carcinoma (19/42), but not in other types of cancer (lymphoma and rhabdomyosarcoma) or leukoplakia samples. A subject-based analysis revealed that S. anginosus was solely detected in dental plaque and not in saliva from all 19 S. anginosus-positive squamous cell carcinoma cases. Further, the genotype of S. anginosus isolated from cancer tissue was identical to that from dental plaque of the same patients.

Conclusion: Infection of S. anginosus could occur frequently in oral squamous cell carcinoma and that dental plaque could be a dominant reservoir of the S. anginosus.

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