Postoperative Hyperthermia of Unknown Origin Treated With Dantrolene Sodium

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Postoperative Hyperthermia of Unknown Origin Treated With Dantrolene Sodium
Anesthesia Progress
Volume 52, Issue 1 (Spring 2005)

Hirohito Inada, DDS*, Shigeharu Jinno, DDS, PhD*, Hikaru Kohase, DDS, PhD*, Haruhisa Fukayama, DDS, PhD‹, Masahiro Umino, DDS, PhD*
* Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan; and
‹ Department of Dental Anesthesiology, School of Dental Medicine, Tsurumi University, Tsurumi, Japan.

An 11-year-old girl was scheduled for alveolar cleft bone grafting with an iliac bone under general anesthesia. Anesthesia was performed with 70% nitrous oxide, 30% oxygen, and propofol. On the first and second postoperative day, persistent hyperthermia was observed. Because the administration of diclofenac sodium had not been effective for the hyperthermia, dantrolene sodium was given. Her body temperature gradually dropped and returned to normal level on the fifth postoperative day. The hyperthermia in the present case might have been caused by a rapidly elevated muscle metabolism in response to pain and stress after the propofol anesthesia. The oral administration of dantrolene sodium successfully lowered the patient's high body temperature.

Keywords: Postoperative hyperthermia, Myoglobin, Dantrolene sodium

Received: December 9, 2002; Accepted: October 5, 2004

DOI: 10.2344/0003-3006(2005)52[21:PHOUOT]2.0.CO;2

Address correspondence to Hirohito Inada, DDS, Section of Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyoku, Tokyo 113-8549, Japan; inada.anph@tmd.ac.jp.

© 2007 The American Dental Society of Anesthesiology