Parallels between Tooth Development and Repair: Conserved Molecular Mechanisms following Carious and Dental Injury

Parallels between Tooth Development and Repair: Conserved Molecular Mechanisms following Carious and Dental Injury
2004
By T.A. Mitsiadis1, and C. Rahiotis2
1 Department of Craniofacial Development, Floor 27, GKT Dental Institute, KingÇƒÙs College, GuyÇƒÙs Hospital, London Bridge, London SE1 9RT, UK
2 Department of Oral Biology, Dental Institute, University of Athens, Thivon 2 Street, 115 27, Goudi, Athens, Greece;
Journal of Dental Research
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Abstract
The reparative mechanisms that operate following carious and traumatic dental injury are critical for pulp survival and involve a series of highly conserved processes. It appears that these processes share genetic programsÇƒÓlinked to cytoskeletal organization, cell movement, and differentiationÇƒÓthat occur throughout embryogenesis. Reactionary dentin is secreted by surviving odontoblasts in response to moderate stimuli, leading to an increase in metabolic activity. In severe injury, necrotic odontoblasts are replaced by other pulp cells, which are able to differentiate into odontoblast-like cells and produce a reparative dentin. This complex process requires the collaborative efforts of cells of different lineage. The behavior of each of the contributing cell types during the phases of proliferation, migration, and matrix synthesis as well as details of how growth factors control wound cell activities are beginning to emerge. In this review, we discuss what is known about the molecular mechanisms involved in dental repair.