Octenidine in root canal and dentine disinfection ex vivo

Octenidine in root canal and dentine disinfection ex vivo
Published article online:
30 Aug 2007
Issue online:
11 Oct 2007
Received 9 December 2006; accepted 5 March 2007
To cite this article: L. Tandjung, T. Waltimo, I. Hauser, P. Heide, E.-M. Decker, R. Weiger (2007) Octenidine in root canal and dentine disinfection ex vivo
International Endodontic Journal 40 (11) , 845Ò851 doi:10.1111/j.1365-2591.2007.01279.x
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L. Tandjung11Department of Periodontology, Endodontology and Cariology, University of Basel, Basel, Switzerland, T. Waltimo22Institute of Preventive Dentistry and Oral Microbiology, University of Basel, Basel, Switzerland, I. Hauser22Institute of Preventive Dentistry and Oral Microbiology, University of Basel, Basel, Switzerland, P. Heide33Pharmacy of the University of T?bingen, T?bingen, Germany, E.-M. Decker44Department of Conservative Dentistry, School of Dental Medicine, University of T?bingen, T?bingen, Germany & R. Weiger11Department of Periodontology, Endodontology and Cariology, University of Basel, Basel, Switzerland

Prof. (Dr) Roland Weiger, Department of Periodontology, Endodontology and Cariology, School of Dental Medicine, University of Basel, Hebelstrasse 3, CH-4056 Basel, Switzerland (Tel.: +41 61 267 26 19; fax: +41 61 267 26 59; e-mail: roland.weiger@unibas.ch).
Tandjung L, Waltimo T, Hauser I, Heide P, Decker E-M, Weiger R. Octenidine in root canal and dentine disinfection ex vivo. International Endodontic Journal, 40, 845Ò851, 2007.

Abstract

Aim The aim of the present study was to investigate the antimicrobial activity of octenidine on Enterococcus faecalis ATCC 29212 in a dentine block model.

Methodology Fifty-six root segments of extracted human teeth were infected with E. faecalis for 4 weeks. Octenidine-phenoxyethanol gel (1 : 1) was applied for different timing: 1 min, 10 min, 7 days and in a different formula (1 : 3) for 10 min. Three samples were chosen for the group with placebo gel and for the group without infection (negative control). Dentine samples were collected, and the total count of bacteria and colony-forming units were determined. In addition, for controls and the 10 min group with 1 : 1 gel, the proportion of viable bacteria (PVB) was assessed.

Results Octenidine was particularly effective after incubation periods of 10 min and 7 days. The mean PVB decreased significantly from 57.2% to 5.7% after 10 min application. After 7 days, only one of 10 samples showed positive culture.

Conclusion The present study showed the effectiveness of octenidine against E. faecalis in dentine disinfection. Further laboratory and clinical studies are required.

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