ORAL DEVICES AND METHODS FOR CONTROLLED DRUG DELIVERY

ORAL DEVICES AND METHODS FOR CONTROLLED DRUG DELIVERY
European Patent Office
Patent number: WO2004069076
Publication date: 2004-08-19
Inventor: WOLFF ANDY [IL]; BEISKI BEN Z [IL]; SELA YORAM [IL]
Applicant: WOLFF ANDY [IL];; BEISKI BEN Z [IL];; SELA YORAM [IL]
Classification:
- international: A61C
- european:
Application number: WO2004IL00123 20040208
Priority number(s): US20030445228P 20030206; US20030668274 20030924
Abstract of WO2004069076

Controlled-drug-delivery oral devices are implanted or inserted into an oral cavity, built onto a prosthetic tooth crown, a denture plate, braces, a dental implant, or the like. The devices are refilled or replaced as needed. The controlled drug delivery may be passive, based on a dosage form, or electro-mechanically controlled, for a high-precision, intelligent, drug delivery. Additionally, the controlled delivery may be any one of the following: delivery in accordance with a preprogrammed regimen, delivery at a controlled rate, delayed delivery, pulsatile delivery, chronotherapeutic delivery, closed-loop delivery, responsive to a sensor's input, delivery on demand from a personal extracorporeal system, delivery regimen specified by a personal extracorporeal system, delivery on demand from a monitoring center, via a personal extracorporeal system, and delivery regimen specified by a monitoring center, via a personal extracorporeal system. Drug absorption in the oral cavity may be assisted or induced by a transport mechanism, such as any one of, or a combination of iontophoresis, electroosmosis, electrophoresis, electroporation, sonophoresis, and ablation. The oral devices require refilling or replacement at relatively long intervals of weeks or months, maintain a desired dosage level in the oral cavity, hence in the gastrointestinal tract, for extended periods, address situations of narrow drug therapeutic indices, and by being automatic, ensure adherence to a prescribed medication regimen. The oral devices and methods for controlled drug delivery apply to humans and animals.