Nuclear Factor B p65 Phosphorylation in Orthodontic Tooth Movement - Corrective Dentistry (Orthodontics) Articles

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http://jdr.iadrjournals.org/cgi/content/abstract/86/6/556?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=orthodontics&searchid=1&FIRSTINDEX=10&sortspec=relevance&resourcetype=HWCIT

Nuclear Factor B p65 Phosphorylation in Orthodontic Tooth Movement
Journal of Dental Research 86(6):556-559, 2007

J. Zuo, L.A. Archer, A. Cooper, K.L. Johnson, L.S. Holliday, and C. Dolce*
Department of Orthodontics, 1600 SW Archer Road, Campus Box 100444, University of Florida College of Dentistry, Gainesville, FL 32610, USA

* corresponding author, cdolce@dental.ufl.edu

Osteoclasts play a vital role in orthodontic tooth movement. Transactivation of nuclear factor B (NFB) by phosphorylation of the p65 component of NFB at amino acid 536 (p65*536) plays a role in osteoclast differentiation stimulated by receptor activator of nuclear factor B-ligand (RANK-L). We hypothesized that this transactivation pathway might be involved in the responses of alveolar bone cells during orthodontic tooth movement. We detected sharp increases in the levels of p65*536 3 and 12 hrs after the application of orthodontic stimuli in rats. In cell culture, osteoclast-like cells displayed no changes in p65*536 in response to RANK-L, but levels rapidly increased after the cells were mechanically scraped. We conclude that p65*536 is produced rapidly in response to orthodontic stimuli and mechanical insults, and may be important in bone remodeling associated with orthodontic tooth movement.

KEY WORDS: osteoclast Ô bone resorption Ô RANK Ô RAW 264.7 Ô osteoclastogenesis

© 2007 International and American Associations for Dental Research