MMPs, IL-1, and TNF are Regulated by IL-17 in Periodontitis

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http://jdr.iadrjournals.org/cgi/content/abstract/86/4/347?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=Periodontitis&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT

MMPs, IL-1, and TNF are Regulated by IL-17 in Periodontitis
J Dent Res 86(4):347-351, 2007

A. Beklen1,2,3, M. Ainola2, M. Hukkanen2,4, C. G?rgan5, T. Sorsa6, and Y.T. Konttinen1,4,7,*
1 Department of Medicine/Invârtes medicin, Helsinki University Central Hospital, Helsinki, Finland;
2 Institute of Biomedicine/Anatomy, University of Helsinki, Finland;
3 Medico-social Centre, Dental Clinic, Bogazici University, Istanbul, Turkey;
4 ORTON Orthopaedic Hospital of the Invalid Foundation, Helsinki, Finland;
5 Department of Periodontology, Faculty of Dentistry, Ankara University, Turkey;
6 Institute of Dentistry, University of Helsinki, Dept. of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland;
7 COXA Hospital for Joint Replacement, Tampere, Finland

* corresponding author, yrjo.konttinen@helsinki.fi, Biomedicum Helsinki, PO Box 700 (Haartmaninkatu 8), FI-00029 HUS-Finland

Periodontitis is characterized by periodontal tissue destruction. Since interleukin-17 (IL-17) has been reported to up-regulate IL-1? and tumor necrosis factor-alpha (TNF-), it was hypothesized that it is increased in periodontitis and up-regulates these cytokines and tissue-destructive matrix metalloproteinases (MMP) in local migrant and resident cells. Immunocytochemistry disclosed elevated IL-1?, TNF-, and IL-17 levels in periodontitis. These cytokines induced proMMP-1 and especially MMP-3 in gingival fibroblasts, whereas MMP-8 and MMP-9 were not induced. IL-17 was less potent as a direct MMP inducer than IL-1? and TNF-, but it induced IL-1? and TNF- production from macrophages, and IL-6 and IL-8 from gingival fibroblasts. In accordance with these findings, immunocytochemistry disclosed that MMP-1 and MMP-3 were increased in periodontitis. Gingival fibroblasts may play an important role in tissue destruction in periodontitis via cytokine-inducible MMP-1 and MMP-3 production, in which IL-17 plays a role as a key regulatory cytokine.

KEY WORDS: IL-1? Ô TNF- Ô IL-17 Ô MMP Ô periodontitis

© 2007 International and American Associations for Dental Research