Insertion stabilizers for implants - Dental Patent Articles

Insertion stabilizers for implants
USPTO Patent Full-Text and Database
Ito , et al
US Patent Number: 6,692,758
Publication Date: February 17, 2004
Inventors: Ito; Masatoshi (Yokohama, JP); Kawai; Yuriko (Kamakura, JP); Okazaki; Seiji (Kamakura, JP); Tanahashi; Masahiko (Kamakura, JP); Kim; Kang Jung (Tokyo, JP); Iwase; Miho (Chigasaki, JP)
Assignee: Toray Industries, Inc. (Tokyo, JP)
Appl. No.: 806151
Filed: March 28, 2001
PCT Filed: July 26, 2000
PCT NO: PCT/JP00/04794
PCT PUB.NO.: WO01/08690
PCT PUB. Date: February 8, 2001
Abstract:
The present invention relates to an implant attachment stabilizer having, as an effective component, a methanebisphosphonic acid derivative represented by general formula (I) ##STR1## [where, in the formula, X, Y, m, n, {character pullout}, A, B, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined in the Specification], or hydrate thereof. The methanebisphosphonic acid derivatives represented by general formula (I) or the hydrates thereof, to which the present invention relates, have an interstitial tissue proliferation inhibiting action and an osteolytic factor production inhibiting action and, in particular, since they inhibit osteolysis through the inhibition of the interstitial tissue proliferation which accompanies implant attachment and the inhibition of osteolysis factor production at the implant periphery, they are effective in the prevention of implant loosening and detachment, and it is possible to extend the implant attachment period in the case of implants such as artificial joints, and implants in the oro-dental field.