Improvement in biocompatibility of ZrO2ÇƒÏAl2O3 nano-composite by addition of HA

Improvement in biocompatibility of ZrO2ÇƒÏAl2O3 nano-composite by addition of HA
Received 22 November 2003; accepted 24 February 2004. Available online 16 April 2004.
Young-Min Kong, Chang-Jun Bae, Su-Hee Lee, Hae-Won Kim and Hyoun-Ee Kim
Biomaterials
Volume 26, Issue 5 , February 2005, Pages 509-517
ScienceDirect
School of Materials Science and Engineering, Seoul National University, Seoul 151-744, South Korea
Abstract
The biocompatibility of zirconiaÇƒÏalumina (ZA) nano-composites in load-bearing applications such as dental/orthopedic implants was significantly enhanced by the addition of bioactive HA. The ZA matrix was composed of nano-composite powder obtained from the Pechini process and had higher flexural strength than conventionally mixed zirconiaÇƒÏalumina composite. Because the ZA nano-composite powder effectively decreased the contact area between HA and zirconia for their reaction during the sintering process, the HA-added ZA nano-composites contained biphasic calcium phosphates (BCP) of HA/TCP and had higher flexural strength than conventionally mixed ZAÇƒÏHA composite. From the in vitro test with osteoblastic cell-lines, the proliferation and the differentiation (as expressed by the alkaline phosphatase activity) of the cellular response on the HA-added ZA nano-composites gradually increased as the amount of HA added increased. From the mechanical and biological evaluations of the HA-added ZA nano-composites, 30HA (30 vol% HA+70 vol% ZA) was found to be the optimal composition for load-bearing biological applications.
Author Keywords: Hydroxyapatite (HA); ZirconiaÇƒÏAlumina (ZA); Nano-composite; In vitro; Alkaline phosphatase
Corresponding author. Tel.: +82-2-880-7161; fax: +82-2-884-1413
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