Gelatinase B is associated with peri-implant bone loss
December 2003
Ma J, Kitti U, Hanemaaijer R, Teronen OP, Sorsa TA, Natah S, Tensing E-K, Konttinen YT
Clinical Oral Implants Research, December 2003, vol. 14, no. 6, pp. 709-713(5)
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Abstract:
The aim of this study was to clear whether gelatinase B is associated with peri-implant bone loss (PBL). Peri-implant sulcus fluid was collected from 46 implant sites in 12 patients. These sites were also characterized using modified Gingival Index (mGI). Activated and total gelatinase B levels, measured using a modified urokinase assay, showed correlation with PBL (n=46, Spearman's rank correlation test). Activated and total gelatinase B values were significantly higher in PBL>3 mm group (n=6) compared to PBL<1 mm (n=29) and 1 <PBL<3 mm (n=11) groups (rank sum test). Activated gelatinase B level in mGI>0.5 group (n=24) was clearly higher compared to mGI=0 (n=13) and ples0.5 (n=9) groups (Rank sum test). We conclude that gelatinase B is associated with PBL. Activation of gelatinase B together with elevated mGI eventually reflect active phases of peri-implantitis and may prove to be diagnostically useful.
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