Effect of synthetic peptides on osteoblast adhesion

Effect of synthetic peptides on osteoblast adhesion
Received 23 June 2004; accepted 15 November 2004. Available online 23 December 2004.
Monica Dettina, , 1, , Maria Teresa Conconib, 1, Roberta Gambarettoa, Andrea Bagnoa, Carlo Di Belloa, Anna Michela Mentib, Claudio Grandib and Pier Paolo Parnigottob
Biomaterials
Volume 26, Issue 22 , August 2005, Pages 4507-4515
ScienceDirect
aDepartment of Chemical Process Engineering, University of Padova, via Marzolo 9, 35131 Padova, Italy
bDepartment of Pharmaceutical Sciences, University of Padova, via Marzolo 5, 35131 Padova, Italy
Abstract
The quality of the early cell/material interactions is responsible for the long-term functional properties of any implanted device. Accordingly, ǃ?next generationǃ? dental/orthopedic biomaterials should be able to promote osteoblast adhesion thus improving the integration process between surgically placed implants and biological tissues. Recent studies have identified a wide range of biochemical signals that can be exploited to promote adhesion, migration, proliferation and differentiation of cells. The clinical use of natural factors to promote osteoblast adhesion is complicated because those are often insoluble and unstable macromolecules and, in addition, it is difficult to obtain them in high quantities, with good purity grade and at low cost. A valid alternative could be the use of short peptides carrying the minimum active sequence of the natural macromolecular factor. This paper describes the properties of two classes of peptides, promoting different adhesion mechanisms, to enhance rat bone marrow osteoblast adhesion both to polystyrene and to acellular bone matrix.
Keywords: Peptide; Cell adhesion; Adhesion molecule; Adsorption; Bioactivity

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1 These authors contributed equally to this work.
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