Effect of stannous fluoride toothpaste on erosion-like lesions: an in vivo study

Effect of stannous fluoride toothpaste on erosion-like lesions: an in vivo study
Issue online:
05 Jun 2006
Accepted for publication March 2006
To cite this article: Alix Young, Per S. Thrane, Erik Saxegaard, Grazyna Jonski, Gunnar Ràlla (2006) Effect of stannous fluoride toothpaste on erosion-like lesions: an in vivo study
European Journal of Oral Sciences 114 (3) , 180Ò183 doi:10.1111/j.1600-0722.2006.00354.x
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Alix Young1,21Department of Cariology2Oral Research Laboratory, Per S. Thrane2,32Oral Research Laboratory3Department of Pathology, Erik Saxegaard2,42Oral Research Laboratory4Department of Prosthetic Dentistry, Dental Faculty, University of Oslo, Norway, Grazyna Jonski22Oral Research Laboratory, Gunnar Ràlla22Oral Research Laboratory

Alix Young, Department of Cariology, Faculty of Dentistry, University of Oslo, PO Box 1109 Blindern, N-0317 Oslo, Norway
Telefax: +47Ò22Ò852344
E-mail: alixr@odont.uio.no
Young A, Thrane PS, Saxegaard E, Jonski G, Ràlla G. Effect of stannous fluoride toothpaste on erosion-like lesions: an in vivo study. Eur J Oral Sci 2006; 114: 180Ò183. © 2006 The Authors. Journal compilation © 2006 Eur J Oral Sci

Abstract
It has recently been shown that stannous fluoride (SnF2), in the form of aqueous solutions and as toothpaste, can reduce the dissolution of enamel in erosive acids in vitro and in situ. The aim of this study was to compare the effect of toothpastes containing SnF2 or NaF on enamel dissolution using an in vivo model. Four healthy anterior teeth in each subject (n = 20) were exposed to diluted citric acid (100 mmol l−1 or 10 mmol l−1) applied using a peristaltic pump (5 ml @7 ml min−1) and the acid was collected in a test tube before and after application of the respective toothpastes (etch I and etch II). Toothpaste was applied to the labial surfaces with a soft brush (four applications, each of 1-min duration), with gentle water rinsing between applications. Each subject had one pair of teeth treated with each of the test toothpastes. Enamel dissolution was examined by assessment of calcium content in the citric acid applied before and after the treatment with toothpaste. The results indicate that the SnF2 toothpaste markedly reduced the dissolution of teeth in vivo (etch II < etch I), whereas the NaF toothpaste provided no protection (etch II > etch I). Toothpaste appears to be an acceptable vehicle for SnF2 and maintains the dissolution-reducing effect exhibited by aqueous solutions of this fluoride salt.

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