Cardiovascular Effects of Felypressin

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Cardiovascular Effects of Felypressin
Anesthesia Progress
Volume 53, Issue 4 (Winter 2006)

Rodrigo Cecanho, DDS, ScD*, Laurival Antonio De Luca Jr, ScD‹, Jos» Ranali, DDS, ScD·
* Professor of Dentistry, School SÑo Leopoldo Mandic, Campinas, Brazil
‹ Professor of Dentistry, School of AraraquaraÛUNESP, Araraquara, Brazil
· Professor of Dentistry, School of PiracicabaÛUNICAMP, Piracicaba, Brazil

Cardiovascular effects of felypressin (FEL) were studied in Wistar rats. Heart rate and mean arterial pressure measurements were taken in awake rats treated with vasopressin (AVP), FEL, or epinephrine (EPI). Each group received either an intravenous (IV) or an intracerebroventricular V1 receptor antagonist, saline, area postrema removal, or sham surgery. Analysis of variance and Student-Newman-Keuls (P < .05) were applied. Felypressin and AVP induced a pressor effect, and bradycardia was inhibited by IV V1 antagonist. Intracerebroventricular V1 antagonist and area postrema removal enhanced their pressor effects. Epinephrine induced a higher pressor effect and a similar bradycardia that was not affected by the treatments. It was concluded that FEL depends on V1 receptors to induce pressor and bradycardic effects, and that it produces a high relationship between bradycardia and mean arterial pressure variation depending on area postrema and central V1 receptors. These effects are potentially less harmful to the cardiovascular system than the effects of EPI.

Keywords: Anesthesia, local, Vasoconstrictor agents, Blood pressure, Baroreflex, Vasopressin

Received: June 27, 2005; Accepted: August 7, 2006

DOI: 10.2344/0003-3006(2006)53[119:CEOF]2.0.CO;2

Address correspondence to Rodrigo Cecanho, Dentistry School SÑo Leopoldo Mandic, R. Jos» Rocha Junqueira, 13, Ponte Preta, Campinas, SP, Brazil, CEP 13041-445; rodrigocecanho@slmandic.com.br.

© 2007 The American Dental Society of Anesthesiology