Anesthetic Efficacy of Lidocaine/Meperidine for Inferior Alveolar Nerve Blocks

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Anesthetic Efficacy of Lidocaine/Meperidine for Inferior Alveolar Nerve Blocks
Anesthesia Progress
Volume 53, Issue 4 (Winter 2006)

Amanda Goodman, DDS, MS*, Al Reader, DDS, MS‹, John Nusstein, DDS, MS·, Mike Beck, DDS, MA?, and Joel Weaver, DDS, PhD ||
* Formerly graduate student in endodontics at The Ohio State University, currently in private practice limited to endodontics, Chicago, Illinois
‹ Professor and Program Director of Graduate Endodontics, Section of Endodontics, The Ohio State University, Columbus, Ohio
· Associate Professor and Chair, Section of Endodontics, The Ohio State University, Columbus, Ohio
? Associate Professor, Section of Oral Biology, The Ohio State University, Columbus, Ohio
|| Professor and Program Director of Anesthesiology, Section of Oral Surgery, Oral Pathology, and Anesthesiology, The Ohio State University, Columbus, Ohio

The authors, using a crossover design, randomly administered, in a single-blind manner, inferior alveolar nerve blocks using 36 mg of lidocaine with 18 μg of epinephrine or a combination of 36 mg of lidocaine with 18 μg epinephrine plus 36 mg meperidine with 18 μg of epinephrine, at 2 separate appointments, to 52 subjects. An electric pulp tester was used to test for anesthesia, in 4-minute cycles for 60 minutes, of the molars, premolars, and central and lateral incisors. Anesthesia was considered successful when 2 consecutive 80 readings were obtained within 15 minutes and the 80 reading was continuously sustained for 60 minutes. Using the lidocaine solution, successful pulpal anesthesia ranged from 8 to 58% from the central incisor to the second molar. Using the lidocaine/meperidine solution, successful pulpal anesthesia ranged from 0 to 17%. There was a significant difference (P < .05) between the lidocaine and lidocaine/meperidine solutions for the lateral incisors through the second molars. We conclude that the addition of meperidine to a standard lidocaine solution does not increase the success of the inferior alveolar nerve block.

Keywords: Meperidine, Inferior alveolar nerve block, Lidocaine

Received: August 28, 2006; Accepted: September 1, 2006

DOI: 10.2344/0003-3006(2006)53[131:AEOMFI]2.0.CO;2

Address correspondence to Dr Al Reader, Department of Endodontics, College of Dentistry, The Ohio State University, 305 W. 12th Avenue, Columbus, OH 43210; reader.2@osu.edu.

© 2007 The American Dental Society of Anesthesiology