ALP activity decreased in compressed PDL cells obtained from severe orthodontically root resorption - Corrective Dentistry (Orthodontics) Articles

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ALP activity decreased in compressed PDL cells obtained from severe orthodontically root resorption
Orthodontic Waves
Volume 66, Issue 3, September 2007, Pages 67-72

Genichiro Kariya, Takashi Nariyasu, Masaru Yamaguchi, Ryo Nakajima, Machi Takano, Takamasa Yoshida, Shouji Fujit, and Kazutaka Kasaia,
Department of Orthodontics, Nihon University School of Dentistry at Matsudo, 2-870-1 Sakaecho-Nishi, Matsudo City, Chiba 271-8587, Japan
Received 1 December 2006; revised 10 April 2007; accepted 14 April 2007. Available online 21 May 2007.

Alkaline phosphatase (ALP) plays an important role in periodontal ligament (PDL) itself and alveolar bone in relation of calcification. However, very little is known about the relationship between external apical root resorption (EARR) during orthodontic treatment and ALP.

We examined the effect of compressive force (CF) on ALP activity in human PDL (HPDL) cells from patients with severe orthodontically induced EARR. ALP activity, PGE2 and IL-1Ç release were determined. The decrease of ALP and the increase of PGE2 and IL-1Ç were greater in the severe root resorption (SRR) group than in the non-resorption (NR) group (p < 0.001, two-way repeated measured ANOVA). NS-398, selective cyclooxygenase-2 (COX-2) inhibitor, and/or IL-1Ç antibody partially prevented the decrease in ALP activity. The presence of both factors together prevented almost completely the decrease in ALP activity to the control level (p < 0.001).

Therefore, the decrease in ALP activity was mediated mainly by PGE2 and IL-1Ç produced by compressed PDL cells obtained from SRR. These results suggest that the decrease of ALP in compressed HPDL cells may be highly involved in the incidence of severe EARR during orthodontic treatment.

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